"Zebra is the American medical slang for arriving at an exotic medical diagnosis when a more commonplace explanation is more likely. It is shorthand for the aphorism coined in the late 1940s by Dr. Theodore Woodward, professor at the University of Maryland School of Medicine, who instructed his medical interns: 'When you hear hoofbeats, think of horses not zebras'. 
The aphorism is an important caution against biases when teaching medical students to weigh medical evidence."*
The zebra is a common image used among the rare disease community. Many rare disease groups as well as individuals identify themselves with the Zebra - they are rare and unique. 
The close cropping of the image is meant to convey the message of boldness and reality of existence. 
The zebra illustration is framed by a shield. Shields are used by many educational institutions to represent strength and safety. It also symbolizes stability, protection, confidence, toughness and no surrender. 
The color blue is a color of calmness, stability and trust.
*https://en.wikipedia.org/wiki/Zebra_(medicine) 
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